Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction
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چکیده
منابع مشابه
Toll-like receptor (TLR)-7 and -8 modulatory activities of dimeric imidazoquinolines.
Toll-like receptors (TLRs) are pattern recognition receptors that recognize specific molecular patterns present in molecules that are broadly shared by pathogens but are structurally distinct from host molecules. The TLR7-agonistic imidazoquinolines are of interest as vaccine adjuvants given their ability to induce pronounced Th1-skewed humoral responses. Minor modifications on the imidazoquino...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2012
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml300079e